Ontology highlight
ABSTRACT:
SUBMITTER: Richards AL
PROVIDER: S-EPMC4754044 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Richards A L AL Leonenko G G Walters J T JT Kavanagh D H DH Rees E G EG Evans A A Chambert K D KD Moran J L JL Goldstein J J Neale B M BM McCarroll S A SA Pocklington A J AJ Holmans P A PA Owen M J MJ O'Donovan M C MC
Human molecular genetics 20160105 5
Schizophrenia is a highly heritable disorder. Genome-wide association studies based largely on common alleles have identified over 100 schizophrenia risk loci, but it is also evident from studies of copy number variants (CNVs) and from exome-sequencing studies that rare alleles are also involved. Full characterization of the contribution of rare alleles to the disorder awaits the deployment of sequencing technology in very large sample sizes, meanwhile, as an interim measure, exome arrays allow ...[more]