Dataset Information

Anthropometric Factors and Thyroid Cancer Risk by Histological Subtype: Pooled Analysis of 22 Prospective Studies.

ABSTRACT:

Background

Greater height and body mass index (BMI) have been associated with an increased risk of thyroid cancer, particularly papillary carcinoma, the most common and least aggressive subtype. Few studies have evaluated these associations in relation to other, more aggressive histologic types or thyroid cancer-specific mortality.

Methods

This large pooled analysis of 22 prospective studies (833,176 men and 1,260,871 women) investigated thyroid cancer incidence associated with greater height, BMI at baseline and young adulthood, and adulthood BMI gain (difference between young-adult and baseline BMI), overall and separately by sex and histological subtype using multivariable Cox proportional hazards regression models. Associations with thyroid cancer mortality were investigated in a subset of cohorts (578,922 men and 774,373 women) that contributed cause of death information.

Results

During follow-up, 2996 incident thyroid cancers and 104 thyroid cancer deaths were identified. All anthropometric factors were positively associated with thyroid cancer incidence: hazard ratios (HR) [confidence intervals (CIs)] for height (per 5?cm)?=?1.07 [1.04-1.10], BMI (per 5?kg/m2)?=?1.06 [1.02-1.10], waist circumference (per 5?cm)?=?1.03 [1.01-1.05], young-adult BMI (per 5?kg/m2)?=?1.13 [1.02-1.25], and adulthood BMI gain (per 5?kg/m2)?=?1.07 [1.00-1.15]. Associations for baseline BMI and waist circumference were attenuated after mutual adjustment. Baseline BMI was more strongly associated with risk in men compared with women (p?=?0.04). Positive associations were observed for papillary, follicular, and anaplastic, but not medullary, thyroid carcinomas. Similar, but stronger, associations were observed for thyroid cancer mortality.

Conclusion

The results suggest that greater height and excess adiposity throughout adulthood are associated with higher incidence of most major types of thyroid cancer, including the least common but most aggressive form, anaplastic carcinoma, and higher thyroid cancer mortality. Potential underlying biological mechanisms should be explored in future studies.

SUBMITTER: Kitahara CM

PROVIDER: S-EPMC4754509 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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Publications

Anthropometric Factors and Thyroid Cancer Risk by Histological Subtype: Pooled Analysis of 22 Prospective Studies.

Kitahara Cari M CM McCullough Marjorie L ML Franceschi Silvia S Rinaldi Sabina S Wolk Alicja A Neta Gila G Olov Adami Hans H Anderson Kristin K Andreotti Gabriella G Beane Freeman Laura E LE Bernstein Leslie L Buring Julie E JE Clavel-Chapelon Francoise F De Roo Lisa A LA Gao Yu-Tang YT Gaziano J Michael JM Giles Graham G GG Håkansson Niclas N Horn-Ross Pamela L PL Kirsh Vicki A VA Linet Martha S MS MacInnis Robert J RJ Orsini Nicola N Park Yikyung Y Patel Alpa V AV Purdue Mark P MP Riboli Elio E Robien Kimberly K Rohan Thomas T Sandler Dale P DP Schairer Catherine C Schneider Arthur B AB Sesso Howard D HD Shu Xiao-Ou XO Singh Pramil N PN van den Brandt Piet A PA Ward Elizabeth E Weiderpass Elisabete E White Emily E Xiang Yong-Bing YB Zeleniuch-Jacquotte Anne A Zheng Wei W Hartge Patricia P Berrington de González Amy A

Thyroid : official journal of the American Thyroid Association 20160201 2

<h4>Background</h4>Greater height and body mass index (BMI) have been associated with an increased risk of thyroid cancer, particularly papillary carcinoma, the most common and least aggressive subtype. Few studies have evaluated these associations in relation to other, more aggressive histologic types or thyroid cancer-specific mortality.<h4>Methods</h4>This large pooled analysis of 22 prospective studies (833,176 men and 1,260,871 women) investigated thyroid cancer incidence associated with gr ...[more]

PMID: 26756356

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Dataset Information

Anthropometric Factors and Thyroid Cancer Risk by Histological Subtype: Pooled Analysis of 22 Prospective Studies.

Background

Methods

Results

Conclusion

Publications

Anthropometric Factors and Thyroid Cancer Risk by Histological Subtype: Pooled Analysis of 22 Prospective Studies.

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