Ontology highlight
ABSTRACT:
SUBMITTER: Gray LR
PROVIDER: S-EPMC4754674 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Gray Lawrence R LR Sultana Mst Rasheda MR Rauckhorst Adam J AJ Oonthonpan Lalita L Tompkins Sean C SC Sharma Arpit A Fu Xiaorong X Miao Ren R Pewa Alvin D AD Brown Kathryn S KS Lane Erin E EE Dohlman Ashley A Zepeda-Orozco Diana D Xie Jianxin J Rutter Jared J Norris Andrew W AW Cox James E JE Burgess Shawn C SC Potthoff Matthew J MJ Taylor Eric B EB
Cell metabolism 20150903 4
Gluconeogenesis is critical for maintenance of euglycemia during fasting. Elevated gluconeogenesis during type 2 diabetes (T2D) contributes to chronic hyperglycemia. Pyruvate is a major gluconeogenic substrate and requires import into the mitochondrial matrix for channeling into gluconeogenesis. Here, we demonstrate that the mitochondrial pyruvate carrier (MPC) comprising the Mpc1 and Mpc2 proteins is required for efficient regulation of hepatic gluconeogenesis. Liver-specific deletion of Mpc1 a ...[more]