Ontology highlight
ABSTRACT:
SUBMITTER: Rossi M
PROVIDER: S-EPMC5785257 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Rossi Mario M Zhu Lu L McMillin Sara M SM Pydi Sai Prasad SP Jain Shanu S Wang Lei L Cui Yinghong Y Lee Regina J RJ Cohen Amanda H AH Kaneto Hideaki H Birnbaum Morris J MJ Ma Yanling Y Rotman Yaron Y Liu Jie J Cyphert Travis J TJ Finkel Toren T McGuinness Owen P OP Wess Jürgen J
The Journal of clinical investigation 20180116 2
An increase in hepatic glucose production (HGP) is a key feature of type 2 diabetes. Excessive signaling through hepatic Gs-linked glucagon receptors critically contributes to pathologically elevated HGP. Here, we tested the hypothesis that this metabolic impairment can be counteracted by enhancing hepatic Gi signaling. Specifically, we used a chemogenetic approach to selectively activate Gi-type G proteins in mouse hepatocytes in vivo. Unexpectedly, activation of hepatic Gi signaling triggered ...[more]