Amyloid burden, cerebrovascular disease, brain atrophy, and cognition in cognitively impaired patients.
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ABSTRACT:
SUBMITTER: Ye BS
PROVIDER: S-EPMC5862069 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Publications
Amyloid burden, cerebrovascular disease, brain atrophy, and cognition in cognitively impaired patients.
Ye Byoung Seok BS Seo Sang Won SW Kim Geon Ha GH Noh Young Y Cho Hanna H Yoon Cindy W CW Kim Hee Jin HJ Chin Juhee J Jeon Seun S Lee Jong Min JM Seong Joon-Kyung JK Kim Jae Seung JS Lee Jae-Hong JH Choe Yearn Seong YS Lee Kyung Han KH Sohn Young H YH Ewers Michael M Weiner Michael M Na Duk L DL
Alzheimer's & dementia : the journal of the Alzheimer's Association 20140719 5
<h4>Background</h4>We investigated the independent effects of Alzheimer's disease (AD) and cerebrovascular disease (CVD) pathologies on brain structural changes and cognition.<h4>Methods</h4>Amyloid burden (Pittsburgh compound B [PiB] retention ratio), CVD markers (volume of white matter hyperintensities [WMH] and number of lacunae), and structural changes (cortical thickness and hippocampal shape) were measured in 251 cognitively impaired patients. Path analyses were utilized to assess the effe ...[more]
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