Amyloid burden, cerebrovascular disease, brain atrophy, and cognition in cognitively impaired patients.
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ABSTRACT: Background
We investigated the independent effects of Alzheimer's disease (AD) and cerebrovascular disease (CVD) pathologies on brain structural changes and cognition.Methods
Amyloid burden (Pittsburgh compound B [PiB] retention ratio), CVD markers (volume of white matter hyperintensities [WMH] and number of lacunae), and structural changes (cortical thickness and hippocampal shape) were measured in 251 cognitively impaired patients. Path analyses were utilized to assess the effects of these markers on cognition.Results
PiB retention ratio was associated with hippocampal atrophy, which was associated with memory impairment. WMH were associated with frontal thinning, which was associated with executive and memory dysfunctions. PiB retention ratio and lacunae were also associated with memory and executive dysfunction without the mediation of hippocampal or frontal atrophy.Conclusions
Our results suggest that the impacts of AD and CVD pathologies on cognition are mediated by specific brain regions.
SUBMITTER: Ye BS
PROVIDER: S-EPMC5862069 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Publications
Amyloid burden, cerebrovascular disease, brain atrophy, and cognition in cognitively impaired patients.
Ye Byoung Seok BS Seo Sang Won SW Kim Geon Ha GH Noh Young Y Cho Hanna H Yoon Cindy W CW Kim Hee Jin HJ Chin Juhee J Jeon Seun S Lee Jong Min JM Seong Joon-Kyung JK Kim Jae Seung JS Lee Jae-Hong JH Choe Yearn Seong YS Lee Kyung Han KH Sohn Young H YH Ewers Michael M Weiner Michael M Na Duk L DL
Alzheimer's & dementia : the journal of the Alzheimer's Association 20140719 5
<h4>Background</h4>We investigated the independent effects of Alzheimer's disease (AD) and cerebrovascular disease (CVD) pathologies on brain structural changes and cognition.<h4>Methods</h4>Amyloid burden (Pittsburgh compound B [PiB] retention ratio), CVD markers (volume of white matter hyperintensities [WMH] and number of lacunae), and structural changes (cortical thickness and hippocampal shape) were measured in 251 cognitively impaired patients. Path analyses were utilized to assess the effe ...[more]
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