Ontology highlight
ABSTRACT:
SUBMITTER: Lin SH
PROVIDER: S-EPMC4754761 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Lin Shu-Hai SH Liu Tengfei T Ming Xiaoyan X Tang Zhi Z Fu Li L Schmitt-Kopplin Philippe P Kanawati Basem B Guan Xin-Yuan XY Cai Zongwei Z
Scientific reports 20160216
Cancer was hypothesized to be driven by cancer stem cells (CSCs), but the metabolic determinants of CSC-like phenotype still remain elusive. Here, we present that hexosamine biosynthetic pathway (HBP) at least in part rescues cancer cell fate with inactivation of glycolysis. Firstly, metabolomic analysis profiled cellular metabolome in CSCs of hepatocellular carcinoma using CD133 cell-surface marker. The metabolic signatures of CD133-positive subpopulation compared to CD133-negative cells highli ...[more]