Ontology highlight
ABSTRACT:
SUBMITTER: Ivanovic T
PROVIDER: S-EPMC4755761 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Ivanovic Tijana T Harrison Stephen C SC
eLife 20151127
Membrane fusion is the critical step for infectious cell penetration by enveloped viruses. We have previously used single-virion measurements of fusion kinetics to study the molecular mechanism of influenza-virus envelope fusion. Published data on fusion inhibition by antibodies to the 'stem' of influenza virus hemagglutinin (HA) now allow us to incorporate into simulations the provision that some HAs are inactive. We find that more than half of the HAs are unproductive even for virions with no ...[more]