Ontology highlight
ABSTRACT:
SUBMITTER: Jerrell RJ
PROVIDER: S-EPMC4755854 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Jerrell Rachel J RJ Parekh Aron A
Biomaterials 20160115
ROCK activity increases due to ECM rigidity in the tumor microenvironment and promotes a malignant phenotype via actomyosin contractility. Invasive migration is facilitated by actin-rich adhesive protrusions known as invadopodia that degrade the ECM. Invadopodia activity is dependent on matrix rigidity and contractile forces suggesting that mechanical factors may regulate these subcellular structures through ROCK-dependent actomyosin contractility. However, emerging evidence indicates that the R ...[more]