Ontology highlight
ABSTRACT:
SUBMITTER: Li N
PROVIDER: S-EPMC4755879 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Li Na N Dhar Shilpa S SS Chen Tsai-Yu TY Kan Pu-Yeh PY Wei Yongkun Y Kim Jae-Hwan JH Chan Chia-Hsin CH Lin Hui-Kuan HK Hung Mien-Chie MC Lee Min Gyu MG
Cancer research 20160108 4
Entire or partial deletions of the male-specific Y chromosome are associated with tumorigenesis, but whether any male-specific genes located on this chromosome play a tumor-suppressive role is unknown. Here, we report that the histone H3 lysine 4 (H3K4) demethylase JARID1D (also called KDM5D and SMCY), a male-specific protein, represses gene expression programs associated with cell invasiveness and suppresses the invasion of prostate cancer cells in vitro and in vivo. We found that JARID1D speci ...[more]