NUSAP1 promotes invasion and metastasis of prostate cancer.
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ABSTRACT:
SUBMITTER: Gordon CA
PROVIDER: S-EPMC5444715 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
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NUSAP1 promotes invasion and metastasis of prostate cancer.
Gordon Catherine A CA Gong Xue X Ganesh Durga D Brooks James D JD
Oncotarget 20170501 18
We have previously identified nucleolar and spindle associated protein 1 (NUSAP1) as a prognostic biomarker in early stage prostate cancer. To better understand the role of NUSAP1 in prostate cancer progression, we tested the effects of increased and decreased NUSAP1 expression in cell lines, in vivo models, and patient samples. NUSAP1 promotes invasion, migration, and metastasis, possibly by modulating family with sequence similarity 101 member B (FAM101B), a transforming growth factor beta 1 ( ...[more]
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