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CD4(+) T cell anergy prevents autoimmunity and generates regulatory T cell precursors.

ABSTRACT: The role of anergy, an acquired state of T cell functional unresponsiveness, in natural peripheral tolerance remains unclear. In this study, we found that anergy was selectively induced in fetal antigen-specific maternal CD4(+) T cells during pregnancy. A naturally occurring subpopulation of anergic polyclonal CD4(+) T cells, enriched for self antigen-specific T cell antigen receptors, was also present in healthy hosts. Neuropilin-1 expression in anergic conventional CD4(+) T cells was associated with hypomethylation of genes related to thymic regulatory T cells (Treg cells), and this correlated with their ability to differentiate into Foxp3(+) Treg cells that suppressed immunopathology. Thus, our data suggest that not only is anergy induction important in preventing autoimmunity but also it generates the precursors for peripheral Treg cell differentiation.

SUBMITTER: Kalekar LA

PROVIDER: S-EPMC4755884 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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CD4(+) T cell anergy prevents autoimmunity and generates regulatory T cell precursors.

Kalekar Lokesh A LA Schmiel Shirdi E SE Nandiwada Sarada L SL Lam Wing Y WY Barsness Laura O LO Zhang Na N Stritesky Gretta L GL Malhotra Deepali D Pauken Kristen E KE Linehan Jonathan L JL O'Sullivan M Gerard MG Fife Brian T BT Hogquist Kristin A KA Jenkins Marc K MK Mueller Daniel L DL

Nature immunology 20160201 3

The role of anergy, an acquired state of T cell functional unresponsiveness, in natural peripheral tolerance remains unclear. In this study, we found that anergy was selectively induced in fetal antigen-specific maternal CD4(+) T cells during pregnancy. A naturally occurring subpopulation of anergic polyclonal CD4(+) T cells, enriched for self antigen-specific T cell antigen receptors, was also present in healthy hosts. Neuropilin-1 expression in anergic conventional CD4(+) T cells was associate ...[more]

PMID: 26829766

Dataset Information

CD4(+) T cell anergy prevents autoimmunity and generates regulatory T cell precursors.

Publications

CD4(+) T cell anergy prevents autoimmunity and generates regulatory T cell precursors.

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