Ontology highlight
ABSTRACT:
SUBMITTER: Kalekar LA
PROVIDER: S-EPMC4755884 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Nature immunology 20160201 3
The role of anergy, an acquired state of T cell functional unresponsiveness, in natural peripheral tolerance remains unclear. In this study, we found that anergy was selectively induced in fetal antigen-specific maternal CD4(+) T cells during pregnancy. A naturally occurring subpopulation of anergic polyclonal CD4(+) T cells, enriched for self antigen-specific T cell antigen receptors, was also present in healthy hosts. Neuropilin-1 expression in anergic conventional CD4(+) T cells was associate ...[more]