Ontology highlight
ABSTRACT:
SUBMITTER: Cardenas PD
PROVIDER: S-EPMC4756317 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Cárdenas Pablo D PD Sonawane Prashant D PD Pollier Jacob J Vanden Bossche Robin R Dewangan Veena V Weithorn Efrat E Tal Lior L Meir Sagit S Rogachev Ilana I Malitsky Sergey S Giri Ashok P AP Goossens Alain A Burdman Saul S Aharoni Asaph A
Nature communications 20160215
Steroidal glycoalkaloids (SGAs) are cholesterol-derived molecules produced by solanaceous species. They contribute to pathogen defence but are toxic to humans and considered as anti-nutritional compounds. Here we show that GLYCOALKALOID METABOLISM 9 (GAME9), an APETALA2/Ethylene Response Factor, related to regulators of alkaloid production in tobacco and Catharanthus roseus, controls SGA biosynthesis. GAME9 knockdown and overexpression in tomato and potato alters expression of SGAs and upstream ...[more]