Ontology highlight
ABSTRACT:
SUBMITTER: Schifano JM
PROVIDER: S-EPMC4756823 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Schifano Jason M JM Cruz Jonathan W JW Vvedenskaya Irina O IO Edifor Regina R Ouyang Ming M Husson Robert N RN Nickels Bryce E BE Woychik Nancy A NA
Nucleic acids research 20160105 3
Toxin-antitoxin (TA) systems play key roles in bacterial persistence, biofilm formation and stress responses. The MazF toxin from the Escherichia coli mazEF TA system is a sequence- and single-strand-specific endoribonuclease, and many studies have led to the proposal that MazF family members exclusively target mRNA. However, recent data indicate some MazF toxins can cleave specific sites within rRNA in concert with mRNA. In this report, we identified the repertoire of RNAs cleaved by Mycobacter ...[more]