Ontology highlight
ABSTRACT:
SUBMITTER: Culviner PH
PROVIDER: S-EPMC8317213 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Culviner Peter H PH Laub Michael T MT
Molecular cell 20180531 5
Toxin-antitoxin systems are widely distributed genetic modules that regulate growth and persistence in bacteria. Many systems, including E. coli MazEF, include toxins that are endoribonucleases, but the full set of targets for these toxins remains poorly defined. Previous studies on a limited set of transcripts suggested that MazF creates a pool of leaderless mRNAs that are preferentially translated by specialized ribosomes created through MazF cleavage of mature 16S rRNA. Here, using paired-end ...[more]