Ontology highlight
ABSTRACT:
SUBMITTER: Koyama S
PROVIDER: S-EPMC4757784 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Koyama Shohei S Akbay Esra A EA Li Yvonne Y YY Herter-Sprie Grit S GS Buczkowski Kevin A KA Richards William G WG Gandhi Leena L Redig Amanda J AJ Rodig Scott J SJ Asahina Hajime H Jones Robert E RE Kulkarni Meghana M MM Kuraguchi Mari M Palakurthi Sangeetha S Fecci Peter E PE Johnson Bruce E BE Janne Pasi A PA Engelman Jeffrey A JA Gangadharan Sidharta P SP Costa Daniel B DB Freeman Gordon J GJ Bueno Raphael R Hodi F Stephen FS Dranoff Glenn G Wong Kwok-Kin KK Hammerman Peter S PS
Nature communications 20160217
Despite compelling antitumour activity of antibodies targeting the programmed death 1 (PD-1): programmed death ligand 1 (PD-L1) immune checkpoint in lung cancer, resistance to these therapies has increasingly been observed. In this study, to elucidate mechanisms of adaptive resistance, we analyse the tumour immune microenvironment in the context of anti-PD-1 therapy in two fully immunocompetent mouse models of lung adenocarcinoma. In tumours progressing following response to anti-PD-1 therapy, w ...[more]