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Co-blockade of immune checkpoints and adenosine A2A receptor suppresses metastasis.


ABSTRACT: Immunosuppressive pathways active within the tumor microenvironment must be targeted in combination to sufficiently bolster antitumor immune defenses. Inhibition of A2A adenosine receptor signaling in combination with immune checkpoint blockade enhances CD8(+) T and NK cell anti-metastatic activity. This results in reduced metastatic burden and improved survival in pre-clinical models.

SUBMITTER: Young A 

PROVIDER: S-EPMC4292728 | biostudies-other | 2014 Nov

REPOSITORIES: biostudies-other

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