Genetic influences on dental enamel that impact caries differ between the primary and permanent dentitions.

ABSTRACT: Clinically, primary and permanent teeth are distinct anatomically and the presentation of caries lesions differs between the two dentitions. Hence, the possibility exists that genetic contributions to tooth formation of the two dentitions are different. The purpose of this study was to test the hypothesis that genetic associations with an artificial caries model will not be the same between primary and permanent dentitions. Enamel samples from primary and permanent teeth were tested for microhardness at baseline, after carious lesion creation, and after fluoride application to verify association with genetic variants of selected genes. Associations were found between genetic variants of ameloblastin, amelogenin, enamelin, tuftelin, tuftelin interactive protein 11, and matrix metallopeptida

SUBMITTER: Bayram M 

PROVIDER: S-EPMC4758910 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature