Ontology highlight
ABSTRACT:
SUBMITTER: Lindau A
PROVIDER: S-EPMC4759214 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Lindau Alexandra A Härdtner Carmen C Hergeth Sonja P SP Blanz Kelly Daryll KD Dufner Bianca B Hoppe Natalie N Anto-Michel Nathaly N Kornemann Jan J Zou Jiadai J Gerhardt Louisa M S LM Heidt Timo T Willecke Florian F Geis Serjosha S Stachon Peter P Wolf Dennis D Libby Peter P Swirski Filip K FK Robbins Clinton S CS McPheat William W Hawley Shaun S Braddock Martin M Gilsbach Ralf R Hein Lutz L von zur Mühlen Constantin C Bode Christoph C Zirlik Andreas A Hilgendorf Ingo I
Basic research in cardiology 20160218 2
Macrophages in the arterial intima sustain chronic inflammation during atherogenesis. Under hypercholesterolemic conditions murine Ly6C(high) monocytes surge in the blood and spleen, infiltrate nascent atherosclerotic plaques, and differentiate into macrophages that proliferate locally as disease progresses. Spleen tyrosine kinase (SYK) may participate in downstream signaling of various receptors that mediate these processes. We tested the effect of the SYK inhibitor fostamatinib on hypercholest ...[more]