Ontology highlight
ABSTRACT:
SUBMITTER: Indjeian VB
PROVIDER: S-EPMC4759241 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Indjeian Vahan B VB Kingman Garrett A GA Jones Felicity C FC Guenther Catherine A CA Grimwood Jane J Schmutz Jeremy J Myers Richard M RM Kingsley David M DM
Cell 20160107 1-2
Changes in bone size and shape are defining features of many vertebrates. Here we use genetic crosses and comparative genomics to identify specific regulatory DNA alterations controlling skeletal evolution. Armor bone-size differences in sticklebacks map to a major effect locus overlapping BMP family member GDF6. Freshwater fish express more GDF6 due in part to a transposon insertion, and transgenic overexpression of GDF6 phenocopies evolutionary changes in armor-plate size. The human GDF6 locus ...[more]