Ontology highlight
ABSTRACT:
SUBMITTER: Pyle A
PROVIDER: S-EPMC4759605 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Pyle Angela A Anugrha Haidyan H Kurzawa-Akanbi Marzena M Yarnall Alison A Burn David D Hudson Gavin G
Neurobiology of aging 20151105
Like any organ, the brain is susceptible to the march of time and a reduction in mitochondrial biogenesis is a hallmark of the aging process. In the largest investigation of mitochondrial copy number in Parkinson's disease (PD) to date and by using multiple tissues, we demonstrate that reduced Parkinson DNA (mitochondrial DNA mtDNA) copy number is a biomarker for the etiology of PD. We used established methods of mtDNA quantification to assess the copy number of mtDNA in n = 363 peripheral blood ...[more]