Ontology highlight
ABSTRACT:
SUBMITTER: Ma MT
PROVIDER: S-EPMC4759618 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Ma Michelle T MT Cullinane Carleen C Imberti Cinzia C Baguña Torres Julia J Terry Samantha Y A SY Roselt Peter P Hicks Rodney J RJ Blower Philip J PJ
Bioconjugate chemistry 20150902 2
Two new bifunctional tris(hydroxypyridinone) (THP) chelators designed specifically for rapid labeling with (68)Ga have been synthesized, each with pendant isothiocyanate groups and three 1,6-dimethyl-3-hydroxypyridin-4-one groups. Both compounds have been conjugated with the primary amine group of a cyclic integrin targeting peptide, RGD. Each conjugate can be radiolabeled and formulated by treatment with generator-produced (68)Ga(3+) in over 95% radiochemical yield under ambient conditions in l ...[more]