Ontology highlight
ABSTRACT:
SUBMITTER: Singh G
PROVIDER: S-EPMC7028042 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Chemistry (Weinheim an der Bergstrasse, Germany) 20200109 9
Bifunctional chelators as parts of modular metal-based radiopharmaceuticals are responsible for stable complexation of the radiometal ion and for covalent linkage between the complex and the targeting vector. To avoid loss of complex stability, the bioconjugation strategy should not interfere with the radiometal chelation by occupying coordinating groups. The C9 position of the very stable Cu<sup>II</sup> chelator 3,7-diazabicyclo[3.3.1]nonane (bispidine) is virtually predestined to introduce fu ...[more]