Ontology highlight
ABSTRACT:
SUBMITTER: Marei H
PROVIDER: S-EPMC4759627 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Marei Hadir H Carpy Alejandro A Woroniuk Anna A Vennin Claire C White Gavin G Timpson Paul P Macek Boris B Malliri Angeliki A
Nature communications 20160218
The small GTPase Rac1 has been implicated in the formation and dissemination of tumours. Upon activation by guanine nucleotide exchange factors (GEFs), Rac1 associates with a variety of proteins in the cell thereby regulating various functions, including cell migration. However, activation of Rac1 can lead to opposing migratory phenotypes raising the possibility of exacerbating tumour progression when targeting Rac1 in a clinical setting. This calls for the identification of factors that influen ...[more]