Ontology highlight
ABSTRACT:
SUBMITTER: Zaritsky A
PROVIDER: S-EPMC5461017 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Zaritsky Assaf A Tseng Yun-Yu YY Rabadán M Angeles MA Krishna Shefali S Overholtzer Michael M Danuser Gaudenz G Hall Alan A
The Journal of cell biology 20170516 6
Efficient collective migration depends on a balance between contractility and cytoskeletal rearrangements, adhesion, and mechanical cell-cell communication, all controlled by GTPases of the RHO family. By comprehensive screening of guanine nucleotide exchange factors (GEFs) in human bronchial epithelial cell monolayers, we identified GEFs that are required for collective migration at large, such as SOS1 and β-PIX, and RHOA GEFs that are implicated in intercellular communication. Down-regulation ...[more]