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Acquired multi-azole resistance in Candida tropicalis during persistent urinary tract infection in a dog.

ABSTRACT: Multi-azole resistance acquisition by Candida tropicalis after prolonged antifungal therapy in a dog with urinary candidiasis is reported. Pre- and post-azole treatment isolates were clonally related and had identical silent mutations in the ERG11 gene, but the latter displayed increased azole minimum inhibitory concentrations. A novel frameshift mutation in ERG3 was found in some isolates recovered after resistance development, so it appears unlikely that this mutation is responsible for multi-azole resistance.

SUBMITTER: Alvarez-Perez S

PROVIDER: S-EPMC4760230 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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Acquired multi-azole resistance in Candida tropicalis during persistent urinary tract infection in a dog.

Álvarez-Pérez Sergio S García Marta E ME Cutuli María Teresa MT Fermín María Luisa ML Daza María Ángeles MÁ Peláez Teresa T Blanco José L JL

Medical mycology case reports 20160202

Multi-azole resistance acquisition by Candida tropicalis after prolonged antifungal therapy in a dog with urinary candidiasis is reported. Pre- and post-azole treatment isolates were clonally related and had identical silent mutations in the ERG11 gene, but the latter displayed increased azole minimum inhibitory concentrations. A novel frameshift mutation in ERG3 was found in some isolates recovered after resistance development, so it appears unlikely that this mutation is responsible for multi- ...[more]

PMID: 26949597

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