Ontology highlight
ABSTRACT:
SUBMITTER: Czerwinska AM
PROVIDER: S-EPMC4761802 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Czerwinska Areta M AM Grabowska Iwona I Archacka Karolina K Bem Joanna J Swierczek Barbara B Helinska Anita A Streminska Wladyslawa W Fogtman Anna A Iwanicka-Nowicka Roksana R Koblowska Marta M Ciemerych Maria A MA Ciemerych Maria A MA
Stem cells and development 20160119 4
The transcription factor Pax7 plays a key role during embryonic myogenesis and sustains the proper function of satellite cells, which serve as adult skeletal muscle stem cells. Overexpression of Pax7 has been shown to promote the myogenic differentiation of pluripotent stem cells. However, the effects of the absence of functional Pax7 in differentiating embryonic stem cells (ESCs) have not yet been directly tested. Herein, we studied mouse stem cells that lacked a functional Pax7 gene and charac ...[more]