Ontology highlight
ABSTRACT:
SUBMITTER: Lee SW
PROVIDER: S-EPMC4344521 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Lee Sae-Won SW Yang Jimin J Kim Su-Yeon SY Jeong Han-Kyul HK Lee Jaewon J Kim Woo Jean WJ Lee Eun Ju EJ Kim Hyo-Soo HS
Nucleic acids research 20150208 4
The importance of epigenetic regulation for maintenance of embryonic stem cell (ESC) pluripotency or for initiation of differentiation is widely accepted. However, the molecular mechanisms are poorly understood. We recently reported that a hypoxic microenvironment induces ESC differentiation. In the present study, we found that hypoxia-responsive histone deacetylase 6 (HDAC6) performs an essential signaling function for myogenic differentiation of ESCs. HDAC6 was downregulated in hypoxic ESCs or ...[more]