Mammalian interspecies substitution of immune modulatory alleles by genome editing.
Ontology highlight
ABSTRACT:
SUBMITTER: Lillico SG
PROVIDER: S-EPMC4761920 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Publications
Mammalian interspecies substitution of immune modulatory alleles by genome editing.
Lillico Simon G SG Proudfoot Chris C King Tim J TJ Tan Wenfang W Zhang Lei L Mardjuki Rachel R Paschon David E DE Rebar Edward J EJ Urnov Fyodor D FD Mileham Alan J AJ McLaren David G DG Whitelaw C Bruce A CB
Scientific reports 20160222
We describe a fundamentally novel feat of animal genetic engineering: the precise and efficient substitution of an agronomic haplotype into a domesticated species. Zinc finger nuclease in-embryo editing of the RELA locus generated live born domestic pigs with the warthog RELA orthologue, associated with resilience to African Swine Fever. The ability to efficiently achieve interspecies allele introgression in one generation opens unprecedented opportunities for agriculture and basic research. ...[more]
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