Ontology highlight
ABSTRACT:
SUBMITTER: Wu J
PROVIDER: S-EPMC5679265 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Wu Jun J Platero-Luengo Aida A Sakurai Masahiro M Sugawara Atsushi A Gil Maria Antonia MA Yamauchi Takayoshi T Suzuki Keiichiro K Bogliotti Yanina Soledad YS Cuello Cristina C Morales Valencia Mariana M Okumura Daiji D Luo Jingping J Vilariño Marcela M Parrilla Inmaculada I Soto Delia Alba DA Martinez Cristina A CA Hishida Tomoaki T Sánchez-Bautista Sonia S Martinez-Martinez M Llanos ML Wang Huili H Nohalez Alicia A Aizawa Emi E Martinez-Redondo Paloma P Ocampo Alejandro A Reddy Pradeep P Roca Jordi J Maga Elizabeth A EA Esteban Concepcion Rodriguez CR Berggren W Travis WT Nuñez Delicado Estrella E Lajara Jeronimo J Guillen Isabel I Guillen Pedro P Campistol Josep M JM Martinez Emilio A EA Ross Pablo Juan PJ Izpisua Belmonte Juan Carlos JC
Cell 20170101 3
Interspecies blastocyst complementation enables organ-specific enrichment of xenogenic pluripotent stem cell (PSC) derivatives. Here, we establish a versatile blastocyst complementation platform based on CRISPR-Cas9-mediated zygote genome editing and show enrichment of rat PSC-derivatives in several tissues of gene-edited organogenesis-disabled mice. Besides gaining insights into species evolution, embryogenesis, and human disease, interspecies blastocyst complementation might allow human organ ...[more]