Ontology highlight
ABSTRACT:
SUBMITTER: Sasamoto Y
PROVIDER: S-EPMC4761963 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Sasamoto Yuzuru Y Hayashi Ryuhei R Park Sung-Joon SJ Saito-Adachi Mihoko M Suzuki Yutaka Y Kawasaki Satoshi S Quantock Andrew J AJ Nakai Kenta K Tsujikawa Motokazu M Nishida Kohji K
Scientific reports 20160222
PAX6 is the key transcription factor involved in eye development in humans, but the differential functions of the two PAX6 isoforms, isoform-a and isoform-b, are largely unknown. To reveal their function in the corneal epithelium, PAX6 isoforms, along with reprogramming factors, were transduced into human non-ocular epithelial cells. Herein, we show that the two PAX6 isoforms differentially and cooperatively regulate the expression of genes specific to the structure and functions of the corneal ...[more]