PON1 as a model for integration of genetic, epigenetic, and expression data on candidate susceptibility genes.

ABSTRACT: Recent genome- and epigenome-wide studies demonstrate that the DNA methylation is controlled in part by genetics, highlighting the importance of integrating genetic and epigenetic data. To better understand molecular mechanisms affecting gene expression, we used the candidate susceptibility gene paraoxonase 1 (PON1) as a model to assess associations of PON1 genetic polymorphisms with DNA methylation and arylesterase activity, a marker of PON1 expression. PON1 has been associated with susceptibility to obesity, cardiovascular disease, and pesticide exposure. In this study, we assessed DNA methylation in 18 CpG sites located along PON1 shores, shelves, and its CpG island in blood specimens collected from newborns and 9-year-old children participating (n<

SUBMITTER: Huen K 

PROVIDER: S-EPMC4762373 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature