Ontology highlight
ABSTRACT:
SUBMITTER: Beckley JR
PROVIDER: S-EPMC4762628 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Beckley Janel R JR Chen Jun-Song JS Yang Yanling Y Peng Junmin J Gould Kathleen L KL
Molecular & cellular proteomics : MCP 20150927 12
Deubiquitinating enzymes (DUBs), cysteine or metallo- proteases that cleave ubiquitin chains or protein conjugates, are present in nearly every cellular compartment, with overlapping protein domain structure, localization, and functions. We discovered a cohort of DUBs that are involved in membrane trafficking (ubp4, ubp5, ubp9, ubp15, and sst2) and found that loss of all five of these DUBs but not loss of any combination of four, significantly impacted cell viability in the fission yeast Schizos ...[more]