Ontology highlight
ABSTRACT:
SUBMITTER: Thawer S
PROVIDER: S-EPMC4763345 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Thawer Sumaiyya S Auret Jennifer J Schnoeller Corinna C Chetty Alisha A Smith Katherine K Darby Matthew M Roberts Luke L Mackay Rosie-Marie RM Whitwell Harry J HJ Timms John F JF Madsen Jens J Selkirk Murray E ME Brombacher Frank F Clark Howard William HW Horsnell William G C WG
PLoS pathogens 20160222 2
Pulmonary epithelial cell responses can enhance type 2 immunity and contribute to control of nematode infections. An important epithelial product is the collectin Surfactant Protein D (SP-D). We found that SP-D concentrations increased in the lung following Nippostrongylus brasiliensis infection; this increase was dependent on key components of the type 2 immune response. We carried out loss and gain of function studies of SP-D to establish if SP-D was required for optimal immunity to the parasi ...[more]