Ontology highlight
ABSTRACT:
SUBMITTER: Pauli A
PROVIDER: S-EPMC4763543 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Pauli Andrea A van Bemmel Joke G JG Oliveira Raquel A RA Itoh Takehiko T Shirahige Katsuhiko K van Steensel Bas B Nasmyth Kim K
Current biology : CB 20101007 20
<h4>Background</h4>Developmental abnormalities observed in Cornelia de Lange syndrome have been genetically linked to mutations in the cohesin machinery. These and other recent experimental findings have led to the suggestion that cohesin, in addition to its canonical function of mediating sister chromatid cohesion, might also be involved in regulating gene expression.<h4>Results</h4>We report that cleavage of cohesin's kleisin subunit in postmitotic Drosophila salivary glands induces major chan ...[more]