Ontology highlight
ABSTRACT:
SUBMITTER: Garea-Rodriguez E
PROVIDER: S-EPMC4763937 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Garea-Rodríguez Enrique E Eesmaa Ave A Lindholm Päivi P Schlumbohm Christina C König Jessica J Meller Birgit B Krieglstein Kerstin K Helms Gunther G Saarma Mart M Fuchs Eberhard E
PloS one 20160222 2
Cerebral dopamine neurotrophic factor (CDNF) belongs to a newly discovered family of evolutionarily conserved neurotrophic factors. We demonstrate for the first time a therapeutic effect of CDNF in a unilateral 6-hydroxydopamine (6-OHDA) lesion model of Parkinson's disease in marmoset monkeys. Furthermore, we tested the impact of high chronic doses of human recombinant CDNF on unlesioned monkeys and analyzed the amino acid sequence of marmoset CDNF. The severity of 6-OHDA lesions and treatment e ...[more]