Bitter taste receptors confer diverse functions to neurons.
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ABSTRACT:
SUBMITTER: Delventhal R
PROVIDER: S-EPMC4764594 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Publications
Bitter taste receptors confer diverse functions to neurons.
Delventhal Rebecca R Carlson John R JR
eLife 20160215
Bitter compounds elicit an aversive response. In Drosophila, bitter-sensitive taste neurons coexpress many members of the Gr family of taste receptors. However, the molecular logic of bitter signaling is unknown. We used an in vivo expression approach to analyze the logic of bitter taste signaling. Ectopic or overexpression of bitter Grs increased endogenous responses or conferred novel responses. Surprisingly, expression of Grs also suppressed many endogenous bitter responses. Conversely, delet ...[more]
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