Extraoral bitter taste receptors in health and disease.
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ABSTRACT:
SUBMITTER: Lu P
PROVIDER: S-EPMC5299619 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Publications
Extraoral bitter taste receptors in health and disease.
Lu Ping P Zhang Cheng-Hai CH Lifshitz Lawrence M LM ZhuGe Ronghua R
The Journal of general physiology 20170104 2
Bitter taste receptors (TAS2Rs or T2Rs) belong to the superfamily of seven-transmembrane G protein-coupled receptors, which are the targets of >50% of drugs currently on the market. Canonically, T2Rs are located in taste buds of the tongue, where they initiate bitter taste perception. However, accumulating evidence indicates that T2Rs are widely expressed throughout the body and mediate diverse nontasting roles through various specialized mechanisms. It has also become apparent that T2Rs and the ...[more]
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