Ontology highlight
ABSTRACT:
SUBMITTER: Abraham A
PROVIDER: S-EPMC4764859 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Abraham Ambily A Natraj Usha U Karande Anjali A AA Gulati Ashutosh A Murthy Mathur R N MR Murugesan Sathyabalan S Mukunda Pavithra P Savithri Handanahal S HS
Scientific reports 20160224
The therapeutic potential of antibodies has not been fully exploited as they fail to cross cell membrane. In this article, we have tested the possibility of using plant virus based nanoparticles for intracellular delivery of antibodies. For this purpose, Sesbania mosaic virus coat protein (CP) was genetically engineered with the B domain of Staphylococcus aureus protein A (SpA) at the βH-βI loop, to generate SeMV loop B (SLB), which self-assembled to virus like particles (VLPs) with 43 times hig ...[more]