Ontology highlight
ABSTRACT:
SUBMITTER: Pan F
PROVIDER: S-EPMC4765929 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Pan Feng F Weeks Ophelia O Yang Feng-Chun FC Xu Mingjiang M
IUBMB life 20150622 6
Ten-eleven translocation (TET) family proteins are dioxygenases that oxidize 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine in DNA, early steps of active DNA demethylation. TET2, the second member of TET protein family, is frequently mutated in patients with hematological malignancies, leading to aberrant DNA methylation profiling and decreased 5hmC levels. Located in the nucleus and acting as a DNA-modifying enzyme, TET2 is thought to exert its function vi ...[more]