Ontology highlight
ABSTRACT:
SUBMITTER: Newman JA
PROVIDER: S-EPMC4766014 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
PloS one 20160224 2
The MAGE (melanoma associated antigen) protein family are tumour-associated proteins normally present only in reproductive tissues such as germ cells of the testis. The human genome encodes over 60 MAGE genes of which one class (containing MAGE-A3 and MAGE-A4) are exclusively expressed in tumours, making them an attractive target for the development of targeted and immunotherapeutic cancer treatments. Some MAGE proteins are thought to play an active role in driving cancer, modulating the activit ...[more]