Ontology highlight
ABSTRACT:
SUBMITTER: Okolotowicz KJ
PROVIDER: S-EPMC4766108 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Okolotowicz Karl J KJ Bushway Paul P Lanier Marion M Gilley Cynthia C Mercola Mark M Cashman John R JR
Bioorganic & medicinal chemistry 20150804 17
Cardiomyopathy is the leading cause of death worldwide. Despite progress in medical treatments, heart transplantation is one of the only current options for those with infarcted heart muscle. Stem cell differentiation technology may afford cell-based therapeutics that may lead to the generation of new, healthy heart muscle cells from undifferentiated stem cells. Our approach is to use small molecules to stimulate stem cell differentiation. Herein, we describe a novel class of 1,5-disubstituted b ...[more]