Ontology highlight
ABSTRACT:
SUBMITTER: Choi HJ
PROVIDER: S-EPMC4766458 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
EMBO reports 20150824 10
The histone H3K27 demethylase, UTX, is a known component of the H3K4 methyltransferase MLL complex, but its functional association with H3K4 methylation in human cancers remains largely unknown. Here we demonstrate that UTX loss induces epithelial-mesenchymal transition (EMT)-mediated breast cancer stem cell (CSC) properties by increasing the expression of the SNAIL, ZEB1 and ZEB2 EMT transcription factors (EMT-TFs) and of the transcriptional repressor CDH1. UTX facilitates the epigenetic silenc ...[more]