Interplay of EMT and CSC in Cancer and the Potential Therapeutic Strategies.
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ABSTRACT:
SUBMITTER: Tanabe S
PROVIDER: S-EPMC7311659 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Interplay of EMT and CSC in Cancer and the Potential Therapeutic Strategies.
Tanabe Shihori S Quader Sabina S Cabral Horacio H Ono Ryuichi R
Frontiers in pharmacology 20200617
The mechanism of epithelial-mesenchymal transition (EMT) consists of the cellular phenotypic transition from epithelial to mesenchymal status. The cells exhibiting EMT exist in cancer stem cell (CSC) population, which is involved in drug resistance. CSCs demonstrating EMT feature remain after cancer treatment, which leads to drug resistance, recurrence, metastasis and malignancy of cancer. In this context, the recent advance of nanotechnology in the medical application has ascended the possibili ...[more]
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