Ontology highlight
ABSTRACT:
SUBMITTER: Branchereau P
PROVIDER: S-EPMC4766471 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Branchereau Pascal P Cattaert Daniel D Delpy Alain A Allain Anne-Emilie AE Martin Elodie E Meyrand Pierre P
Scientific reports 20160225
By acting on their ionotropic chloride channel receptors, GABA and glycine represent the major inhibitory transmitters of the central nervous system. Nevertheless, in various brain structures, depolarizing GABAergic/glycinergic postsynaptic potentials (dGPSPs) lead to dual inhibitory (shunting) and excitatory components, the functional consequences of which remain poorly acknowledged. Indeed, the extent to which each component prevails during dGPSP is unclear. Understanding the mechanisms predic ...[more]