Ontology highlight
ABSTRACT:
SUBMITTER: Martinez-Solorio D
PROVIDER: S-EPMC4767023 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20160202 6
A reusable silicon-based transfer agent (1) has been designed, synthesized, and validated for effective room-temperature palladium-catalyzed cross-coupling reactions (CCRs) of aryl and heteroaryl chlorides with readily accessible aryl lithium reagents. The crystalline, bench-stable siloxane transfer agent (1) is easily prepared via a one-step protocol. Importantly, this "green" CCR protocol circumvents prefunctionalization, isolation of organometallic cross-coupling partners, and/or stoichiometr ...[more]