Ontology highlight
ABSTRACT:
SUBMITTER: Zhang N
PROVIDER: S-EPMC4767064 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Zhang Niannian N Jiang Zhenghui Z Ren Weifeng W Yuan Li L Zhu Yangyi Y
OncoTargets and therapy 20160219
The WW domain-containing oxidoreductase (WWOX) gene is a tumor suppressor gene, the abnormal expression of which will lead to osteosarcoma tumorigenesis. Polymorphisms of the WWOX gene are associated with the risk of several malignancies. We hypothesized that genetic variations in the WWOX gene were related to osteosarcoma risk and outcome. In this case-control study, we recruited 276 young osteosarcoma patients and 286 controls from the East Chinese population and genotyped seven tag single-nuc ...[more]