Ontology highlight
ABSTRACT:
SUBMITTER: Tracy TS
PROVIDER: S-EPMC4767386 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Tracy Timothy S TS Chaudhry Amarjit S AS Prasad Bhagwat B Thummel Kenneth E KE Schuetz Erin G EG Zhong Xiao-Bo XB Tien Yun-Chen YC Jeong Hyunyoung H Pan Xian X Shireman Laura M LM Tay-Sontheimer Jessica J Lin Yvonne S YS
Drug metabolism and disposition: the biological fate of chemicals 20151217 3
The cytochrome P450 (P450) enzymes are the predominant enzyme system involved in human drug metabolism. Alterations in the expression and/or activity of these enzymes result in changes in pharmacokinetics (and consequently the pharmacodynamics) of drugs that are metabolized by this set of enzymes. Apart from changes in activity as a result of drug-drug interactions (by P450 induction or inhibition), the P450 enzymes can exhibit substantial interindividual variation in basal expression and/or act ...[more]