Ontology highlight
ABSTRACT:
SUBMITTER: Rajman I
PROVIDER: S-EPMC5360579 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Rajman Iris I Knapp Laura L Morgan Thomas T Masimirembwa Collen C
EBioMedicine 20170220
Genetic diversity is greater in Africa than in other continental populations. Genetic variability in genes encoding drug metabolizing enzymes may contribute to the high numbers of adverse drug reactions reported in Africa. We reviewed publications (1995-April 2016) reporting frequencies of known cytochrome P450 (CYP) variants in African populations. Using principal components analysis (PCA) we identified CYP alleles of potential clinical relevance with a marked difference in distribution in Afri ...[more]