Ontology highlight
ABSTRACT:
SUBMITTER: Xu YM
PROVIDER: S-EPMC4767476 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Xu Yue-Mei YM Wang Hong-Jiang HJ Chen Fang F Guo Wan-Hua WH Wang Yan-Yang YY Li Hang-Yu HY Tang Jin-Hai JH Ding Ying Y Shen Ya-Chen YC Li Min M Xuan Wen-Ying WY Liu Lin-Hui LH Wang Jia J Wang Xue-Rong XR Gao Ze-Jun ZJ Liang Xiu-Bin XB Su Dong-Ming DM
Oncotarget 20151201 40
HRD1 (3-hydroxy-3-methylglutaryl reductase degradation) is an E3 ubiquitin ligase. We found that HRD1 was significantly downregulated in 170 breast cancer tissues. Low tumoral HRD1 expression was correlated with clinicopathological characteristics and a shorter survival in breast cancer patients. P65 specifically bound to the HRD1 promoter and inhibited HRD1 expression. Suppression of NF-κB activity reversed IL-6-induced downregulation of HRD1 expression. HRD1 interacted with IGF-1R and promoted ...[more]