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Large-Scale Nanoelectrode Arrays to Monitor the Dopaminergic Differentiation of Human Neural Stem Cells.

ABSTRACT: A novel cell-based biosensing platform is developed using a combination of sequential laser interference lithography and electrochemical deposition methods. This enables the sensitive discrimination of dopaminergic cells from other types of neural cells in a completely nondestructive manner. This platform and detection strategy may become an effective noninvasive in situ monitoring tool that can be used to determine stem cell fate for various regenerative applications.

SUBMITTER: Kim TH 

PROVIDER: S-EPMC4767621 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature

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Large-Scale Nanoelectrode Arrays to Monitor the Dopaminergic Differentiation of Human Neural Stem Cells.

Kim Tae-Hyung TH   Yea Cheol-Heon CH   Chueng Sy-Tsong Dean ST   Yin Perry To-Tien PT   Conley Brian B   Dardir Kholud K   Pak Yusin Y   Jung Gun Young GY   Choi Jeong-Woo JW   Lee Ki-Bum KB  

Advanced materials (Deerfield Beach, Fla.) 20150921 41

A novel cell-based biosensing platform is developed using a combination of sequential laser interference lithography and electrochemical deposition methods. This enables the sensitive discrimination of dopaminergic cells from other types of neural cells in a completely nondestructive manner. This platform and detection strategy may become an effective noninvasive in situ monitoring tool that can be used to determine stem cell fate for various regenerative applications. ...[more]

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